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How to get fromSanta Ana to Key Westby plane, train, bus, ferry, or car

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There are 10 ways to get from Santa Ana to Key West by plane, train, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Key West International Airport (EYW)plane plane SNA - EYW
    8h 54m
    $123–485

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Key West International Airport (EYW)plane plane LAX - EYW
    9h 47m
    $122–415

  3. Train, bus, ferry via Irving

    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Houston Bus Stationbus bus
    4. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 15h
    $643–871

  4. Train, bus, ferry

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    4. Take the bus from Gulfport to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 21h
    $1,349–2,129

  5. Drive  2,815.8 mi

    1. Drive from Santa Ana to Key Westcar car 2,815.8 mi
    47h 5m
    $465–672

  6. Train to San Diego International Airport, fly

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Key West International Airport (EYW)plane plane SAN - EYW
    11h 3m
    $145–458

  7. Train, train to Ontario International Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to Ontario Amtraktrain train
    3. Fly from Ontario International Airport (ONT) to Key West International Airport (EYW)plane plane ONT - EYW
    11h
    $162–569

  8. Train to Burbank Bob Hope Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Key West International Airport (EYW)plane plane BUR - EYW
    13h 4m
    $136–492

  9. Bus to Palm Springs International Airport, fly

    1. Take the bus from Fullerton Amtrak Station to Palm Springs Airport Amtrak Bus Stopbus bus
    2. Fly from Palm Springs International Airport (PSP) to Key West International Airport (EYW)plane plane PSP - EYW
    12h 26m

  10. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus
    4d 2h
    $2,350–3,772

Santa Ana to Key West by train, taxi, bus, and foot

Calendar7Weekly Services
Duration4d 2hAverage Duration
Ticket$2,350Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Santa Ana to Key West.ExpandLaunch map view
  • Distance: 2,263.6 mi
  • Duration: 8h 54m

What companies run services between Santa Ana, CA, USA and Key West, FL, USA?

American Airlines and Delta fly from John Wayne Airport Orange County (SNA) to Key West International Airport (EYW) 4 times a day.

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Want to know more about travelling around United States

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