There are 6 ways to get from Mannheim to Lyon by train (TGV), bus, car, train, plane, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhoftrain 12 / ...
- Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain 83 / ...
- Take the train from Strasbourg to Lyon Part Dieutrain Tgv
7h 17m€116–193Bus
cheapest- Take the bus from Mannheim central bus station to Lyonbus N7720 / ...
8h 50m€50–85Drive 597.8 km
- Drive from Mannheim to Lyoncar 597.8 km
5h 59m€110–158Train to Frankfurt, fly
- Take the train from Mannheim, Hauptbahnhof to Frankfurttrain
- Fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS)plane FRA - LYS
4h 37m€144–357Night train, train, bus
- Take the nighttrain from Mannheim Hbf to Basel Sbbnighttrain Nj
- Take the train from Basel SBB to Lausannetrain
- Take the bus from Lausanne Bus Station to Lyon Perrache Bus Stationbus
10h 22m€97–219Train, train to Strasbourg International Airport, fly
- Take the train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhoftrain
- Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain
- Fly from Strasbourg International Airport (SXB) to Lyon–Saint Exupéry Airport (LYS)plane SXB - LYS
5h 18m€138–342
Mannheim to Lyon by train
Comparing Your Travel Options
The cheapest way to get from Mannheim to Lyon is to bus which costs €50 - €85 and takes 8h 50m.
The fastest way to get from Mannheim to Lyon is to train and fly which takes 4h 37m and costs €140 - €360.
Yes, there is a direct bus departing from Mannheim central bus station station and arriving at Lyon. Services depart four times a day, and operate every day. The journey takes approximately 8h 50m.
No, there is no direct train from Mannheim to Lyon. However, there are services departing from Mannheim, Hauptbahnhof and arriving at Lyon Part Dieu via Karlsruhe Hauptbahnhof and Strasbourg. The journey, including transfers, takes approximately 7h 17m.
The distance between Mannheim and Lyon is 646 km. The road distance is 597.8 km.
The best way to get from Mannheim to Lyon without a car is to train which takes 7h 17m and costs €110 - €200.
It takes approximately 7h 17m to get from Mannheim to Lyon, including transfers.
Mannheim to Lyon bus services, operated by FlixBus, depart from Mannheim central bus station.
Mannheim to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
The best way to get from Mannheim to Lyon is to train which takes 7h 17m and costs €110 - €200. Alternatively, you can bus, which costs €50 - €85 and takes 8h 50m.
What companies run services between Mannheim, Germany and Lyon, France?
You can take a train from Mannheim, Hauptbahnhof to Lyon Part Dieu via Karlsruhe Hauptbahnhof, Strasbourg Bahnhof, and Strasbourg in around 7h 17m. Alternatively, FlixBus operates a bus from Mannheim central bus station to Lyon twice daily. Tickets cost €55–85 and the journey takes 8h 50m. BlaBlaCar Bus also services this route twice daily.
- Website
- lufthansa.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–550
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Munich
- Ave. Duration
- 3h 40m
- When
- Monday, Wednesday, Thursday, and Friday
- Estimated price
- €75–240
- Website
- airbus.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–240
- Website
- twinjet.fr
Flights from Strasbourg International Airport to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 10m
- When
- Monday to Friday
- Estimated price
- €440–950
- Website
- airdolomiti.it
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Monday to Saturday
- Estimated price
- €160–550
- Website
- brusselsairlines.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Brussels
- Ave. Duration
- 3h 20m
- When
- Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €75–270
- Website
- airfrance.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Paris Charles de Gaulle
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €55–330
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €9–18
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 43 min
- Frequency
- Every 3 hours
- Estimated price
- €12–24
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Hourly
- Estimated price
- €10–21
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €9–18
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 43 min
- Frequency
- Every 3 hours
- Estimated price
- €12–24
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 57 min
- Frequency
- Every 30 minutes
- Estimated price
- €10
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 57 min
- Frequency
- Every 30 minutes
- Estimated price
- €10
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +43 (0) 5 1717
- Website
- ÖBB EuroCity
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 42 min
- Frequency
- Twice daily
- Estimated price
- €16
- Website
- ÖBB EuroCity
- Website
- ÖBB EuroCity
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 42 min
- Frequency
- Twice daily
- Estimated price
- €16
- Website
- ÖBB EuroCity
- Website
- ÖBB EuroCity
- Phone
- +49 621 830 1200
- Website
- Süwex
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 6m
- Frequency
- 5 times a week
- Estimated price
- €13–19
- Schedules at
- Süwex
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 6m
- Frequency
- 5 times a week
- Estimated price
- €13–19
- Schedules at
- Süwex
- Phone
- +49 6131 4975 022
- [email protected]
- Website
- dbregiobus-mitte.de
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 46m
- Frequency
- Once a week
- Estimated price
- €13–19
- Schedules at
- dbregiobus-mitte.de
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 46m
- Frequency
- Once a week
- Estimated price
- €13–19
- Schedules at
- dbregiobus-mitte.de
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 12m
- Frequency
- Every 4 hours
- Estimated price
- €95–140
- Website
- TGV inOui
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact Details
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €95–150
- Website
- Oui.SNCF
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Mannheim, Hauptbahnhof to Frankfurt
- Ave. Duration
- 31 min
- Frequency
- Once daily
- Estimated price
- €8–15
- Website
- Nederlandse Spoorwegen (NS)
Night train from Mannheim Hbf to Basel Sbb
- Ave. Duration
- 2h 50m
- Frequency
- Twice daily
- Estimated price
- €29–55
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Mannheim Hbf to Basel Sbb
- Ave. Duration
- 2h 47m
- Frequency
- 3 times a day
- Estimated price
- €23–95
- Website
- Nightjet
- Sleeper Carriage
- €85–95
- Couchette Carriage
- €55–65
- Seating Carriage
- €23–28
Train from Basel SBB to Lausanne
- Ave. Duration
- 2h 24m
- Frequency
- Hourly
- Estimated price
- €55–100
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Mannheim central bus station to Lyon
- Ave. Duration
- 8h 50m
- Frequency
- Twice daily
- Estimated price
- €55–85
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Mannheim central bus station to Lyon
- Ave. Duration
- 9h 5m
- Frequency
- Twice daily
- Estimated price
- €50–85
- Website
- BlaBlaCar Bus
- Phone
- +420 222 222 221
- [email protected]
- Website
- RegioJet
Bus from Lausanne Bus Station to Lyon Perrache Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice a week
- Estimated price
- €15–23
- Website
- RegioJet
Want to know more about travelling around France
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Mannheim to Lyon bus services, operated by FlixBus, arrive at Lyon station.
Mannheim to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
Yes, the driving distance between Mannheim to Lyon is 598 km. It takes approximately 5h 59m to drive from Mannheim to Lyon.
Book your Mannheim to Lyon train tickets online with Omio.
Book your Mannheim to Lyon bus tickets online with Omio, FlixBus and 12go.asia.
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