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How to get fromGainesville to Chicagoby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 9 ways to get from Gainesville to Chicago by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Chicago Midway International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW)plane plane GNV - MDW
    6h 37m
    $94–476

  2. Fly Gainesville Regional Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Gainesville Regional Airport (GNV) to Chicago O'Hare International Airport (ORD)plane plane GNV - ORD
    6h 37m
    $68–346

  3. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus FlixBus N2415 / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    23h 5m
    $176–270

  4. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    37h 51m
    $874–1,433

  5. Drive  997.6 mi

    1. Drive from Gainesville to Chicagocar car 997.6 mi
    18h
    $165–238

  6. Bus to Jacksonville, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago Midway International Airport (MDW)plane plane JAX - MDW
    7h 20m
    $145–445

  7. Bus to Jacksonville, fly to Chicago O'Hare International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago O'Hare International Airport (ORD)plane plane JAX - ORD
    7h 49m
    $110–325

  8. Bus to Orlando, fly to Chicago Midway International Airport

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)plane plane MCO - MDW
    7h 2m
    $163–446

  9. Bus to Tampa, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Chicago Midway International Airport (MDW)plane plane TPA - MDW
    9h 22m
    $137–236

Gainesville to Chicago by bus

Calendar25Weekly Buses
Duration23h 5mAverage Duration
Ticket$176Cheapest Price
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Comparing Your Travel Options

Map of how to get from Gainesville to Chicago.ExpandLaunch map view
  • Distance: 906 mi
  • Duration: 6h 37m

What companies run services between Gainesville, FL, USA and Chicago, IL, USA?

Delta, American Airlines, and Southwest Airlines fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, you can take a bus from Gainesville to Chicago Bus Station via Atlanta Bus Station in around 23h 5m.

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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

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